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Both metal ions primarily bind to sulfhydrylgroups such as those on cysteine GSH, or cysteinyl residuesof proteins such as albumin.
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Cytotoxic edema reaches a maximum at48–96 hours, during which time there is a higher risk ofherniation. The role of non-genetic factors, such as epigeneticmodi?ers, on the phenotypic variability observed between affected family membersis not fully understood complicating the creation of personalized therapeutic andsurveillance approaches that may reduce patient mortality.
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